succinic acid pka

Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. The information has not been reviewed or verified by ECHA or any other authority. This section summarises the pH values from all registered dossiers for the substance. Processable data for study results is prioritised by dose descriptor type (see list below) and subsequently further prioritised by the test species. pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre. Note: Registrants can also select ‘other’ as the picklist conclusion. Data is generally standardised and displayed in milligram per kilo soil (dry weight). This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. test not applicable because organic peroxide. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment, generally displayed in milligrams per kilogram sediment (dry weight). The results of matching substance classifications are displayed in percentages of the total number of notifications. pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. Registrants can identify the origin of their substance as being: If more than one type of substance is registered, both types will be displayed. Duis pulvinar non magna ac viverra. Hazard for terrestrial organisms provides information on the substance’s hazard assessment conclusion related to terrestrial organisms/soil. Proin faucibus mollis lectus ut fermentum. ECHA has no public registered data indicating whether or into which articles the substance might have been processed. Thirdly the display of data is prioritised by units. The Agency thus cannot guarantee the correctness of the information displayed. Succinic acid (Succınıc acıd) has been found throughout most human tissues, and has also been detected in most biofluids, including cerebrospinal fluid, breast milk, sweat, and blood. This section provides environmental fate and pathways information compiled from all registered dossiers for the substance. Succinic acid ACS Reagent Product Number 39,805-5 Store at Room Temperature Exact replacement for Product Number S 0141 Product Description Molecular Formula: C4H6O4 Molecular Weight: 118.1 CAS Number: 110-15-6 Melting point: 185-187 °C1 Boiling point: 235 °C (with partial decomposition into the anhydride)1 pKa: 4.21, 5.72 (25 °C) 2 The REACH regulatory processes identified for the Brief Profile are: Persistent Organic Pollutants (POPs)The POPs Regulation (EU) 2019/1021 entered into force on 15 July 2019, repealing the previous POPs Regulation (EC) No 850/2004. 8 Long-term EC10 or LC10 or NOEC for mammals provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the mammals in the test, or the no observed effect concentration for mammals. Data is generally displayed in milligrams per kilogram sediment (dry weight) or in milligram per litre. A substance may have more than one CAS number associated. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Biocidal product authorisation – indicates if authorised biocidal products exist which use this substance as an active ingredient. This substance is used in the following areas: printing and recorded media reproduction, health services and scientific research and development. This section provides an overview of the type of study records behind the presented results and data waving justifications. H Pa m3/mol provides substance information on the substance’s Henry’s Law Constant in Pa m3/mol at a temperature measured in °C and the atmospheric pressure measured in Pascal. These notifications can be provided by manufacturers, importers and downstream users. Numele provine din limba latină succinum (chihlimbar), din care poate fi obținut acidul. If multiple values are available, the most conservative value (the highest percentage) is displayed. Methyl succinic acid appears as white or yellowish crystals or beige powder. Hot sale 99% Succinic acid food grade suppliers in China Buy competitive price Succinic acid/butanedioic acid in China Factory supply Superior Quality Succinic acid producers High purity Qualified Succinic acid manufacturer/wholesale Top quality Succinic Acid powder cost Pure Succinic acid powder Purchase Succinic acid traders Succinic acid mono-3-amino-2,4,6-triiodo-N-ethylanilide Succinic acid, (4-ethoxy-1-napthyl-carbonylmethyl) ester Succinic acid Succinic acid Succinic acid Succinic Acid -- food/medical/industrial grade CAS#110-15-6 CAS NO.110-15-6 supply good quality and best price of Succinic Acid CAS NO.110-15-6 Succinic acid,bis(2-(hexyloxy)ethyl) ester Succinic acid (110-15-6) Succinic acid,CAS 110-15-6 Succinic acid Succinic acid Succinic acid Succinic acid Succinic Acid -- food/medical/industrial grade CAS#110-15-6 Hot sale Succinic Acid with high purity 99.5% min CAS NO.110-15-6 Succinicacid Succinic acid 110-15-6 Succinic acid Succinic acid Succinic acid Succinic acid Succinic acid Succinic Acid Succinic Acid Succinic acid/110-15-6 Succinic acid Loxapine succinate salt Intermediate of paint & dye ---Succinic acid CAS: 110-15-6, BioAmber opens succinic acid facility in Sarnia, Canada, Biologically Derived Succinic Acid (BDSA) Production, Succinic Acid Market Size To Reach $237.8 Million By 2022, BRIEF-BioAmber signs supply agreement for bio-succinic acid in lubricants, Biotechnology of succinic acid production and markets for derived industrial products. Values are displayed in milligram per litre. The IUPAC nomenclature is a systematic way of naming chemical substances, both organic and inorganic. If so, the data provided is not processed for the Brief Profile. 50-00-0 To 1540426-95-6, succinic acid supplier,the acid-base dissociation constants of the chemical succinic acid, Please enter a valid email address.e.g. Explain clearly why the first pKa of malonic acid is lower than the first pKa of succinic acid, and why the second pKa of malonic acid is higher than the second pKa of succinic acid. This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. PNEC STP, data displayed in milligram per litre. Considering the pKa of succinic acid of 4.2 and 5.6 at 25 C (Dean, 1999), at pH 3.5 more than 80% of succinic acid would be in protonated form. SMILES notations are comprised of atoms (designated by elemental symbols), bonds, parentheses (used to show branching), and numbers (used for cyclic structures). List of substances subject to the POPs Regulation - Indicates if the substance is included in the POPs Regulation. h are ideal production targets to compete with oil-based succinic acid production. Data is generally standardised and displayed in in milligram per kilo of food. These numbers start with 6, 7, 8 or 9. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Registrants can choose the same picklist endpoint conclusions as mentioned under ‘Skin sensitisation’. As a diprotic acid, succinic acid undergoes two successive deprotonation reactions: Short-term EC50 or LC50 for mammals provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of mammals in the test, generally displayed in milligram per kilo food. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Remove contact lenses if present and easy to do – continue rinsing. Succinic acid is byproduct of sugar fermentation, and is present in wines and beer. For other data an order of magnitude logic might apply; e.g. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. When radiolabeled with technetium-99m, it is used in a number of types of diagnostic testing. Processable data for summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Classifications under REACH have to be supported by data (support studies). Registrants can choose from the following picklist endpoint conclusions: Inhalation route provides substance information on the substance’s acute toxicity via the inhalation route. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. Danger! Succinic acid pKas: 4.20 and 5.60. Succinic Acid 99,7. The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as critical for human health and/or the environment based on the information provided to the Agency. If the substance has no EC number attributed, ECHA will attribute a list number. This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. Harmonised C&L– indicates if a European Union harmonised classifications and labelling has been assigned to the substance according to Annex VI to CLP and subsequent ATPs. Authorisation list (Annex XIV) – indicates if the substance is included in the Authorisation List. H atm m3/mol provides substance information on the substance’s Henry’s Law Constant in atm m3/mol at a temperature measured in °C and a pressure measured in Pascal. Each InChI string starts with the InChI version number followed by the main layer. Vestibulum tincidunt ultricies libero quis mollis. Brief Profile - Last updated: 19/12/2020 Print. While it is present in the final substance, it was not intentionally added. The Agency thus cannot guarantee the correctness of the information displayed. Degradation rate constant with OH radicals provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. (NTP, 1992) CAMEO Chemicals. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. Annex XVII (Restriction list) – indicates if the substance is included in the list of restrictions. Other names gives any names of any other type, such as common names, synonyms and acronyms. Succinic acid (Succınıc acıd) exists as a solid, soluble (in water), and a weakly acidic compound (based on its pKa). The information provided in the free-text fields is not published in the Brief Profiles. 1), Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.1), Self-heating substances and mixtures (Cat.2), Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.2), Substances or mixtures which in contact with water releases flammable gases (Cat.3), Substances and mixtures which in contact with water emit flammable gases, Contact with water liberates highly flammable gases, Spontaneously flammable in air (pyrophoric), Projection hazard but not a mass explosion hazard (Div. Values are generally displayed in milligram per litre. The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Fusce eget lorem sed purus tempus blandit. Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles. If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C). EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight). Note: Registrants can also select ‘other’ as the type of density. The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Manufacturers and importers can provide the following information in the registration dossier: Hazard for Air provides information on the substance’s hazard assessment conclusion related to air. All data remain the property of its respective owners.Note that the brief profile is an automatically generated summary and that not all available data may be displayed. Inherently biodegradable, fulfilling specific criteria; Inherently biodegradable, not fulfilling specific criteria, Under test conditions no biodegradation observed. organic acids – sorted by formula For example CLH index numbers, CN numbers, deleted CAS numbers, etc. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. The physical state and form of a substance can play a significant impact when the hazards of a substance are assessed. Chemical formula: C 4 H 6 O 4. Data is generally displayed in milligram per kilo bodyweight. This section summarises the flash point values from all registered dossiers for the substance. Also known as: butanedioic acid 100 mM. HPLC Application for Analysis of Sodium Succinate on Primesep 100 Succinic acid is a dicarboxylic acid that plays important role in citric acid cycle. For a detailed overview on identified uses and environmental releases, please consult the detailed information from the registration dossiers. Succinic acid, also called Butanedioic Acid, a dicarboxylic acid of molecular formula C 4 H 6 O 4 that is widely distributed in almost all plant and animal tissues and that plays a significant role in intermediary metabolism. Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C. REACH registration dossiers notifications. This section summarises the density values from all registered dossiers for the substance. In this case, the preferred CAS number is displayed first. Results without measurement conditions (pressure) are not processed for the Brief Profile. Koc at 20°C provides substance information on the substance’s Koc adsorption at a temperature 20 °C. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’. There are four methods to aggregate and summarise data, depending on the available data and endpoint. Percentage distribution in the Media displays the values attributed by the registrants to the following options: For this endpoint registrants do not provide summaries that are processable for the Brief Profile.Type of study provided. Oxidation reduction potential in mV provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature measured in °C. BOD5 provides substance information on the substance’s BOD5 values displayed in O2 (milli)gram per gram test material. If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile: Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. It is possible that the harmonisation is introduced through an amendment to the CLP Regulation. Applicant’s summary and conclusion – Interpretation of results. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. The Brief Profile is produced based on data in ECHA’s databases and maintained by the Agency, and therefore the Brief Profile as a dissemination tool falls under ECHA’s responsibility. Su nombre proviene del latín succinum, que quiere decir ámbar, de donde puede extraerse. The BPR addresses the placing on the market and use of biocidal products, which are used to protect humans, animals, materials or articles against harmful organisms, like pests or bacteria, by regulating the active substances contained in a biocidal product. Therefore this does not constitute official and legally binding information. Translated names gives the names in different EU languages, where available to ECHA. Direct PKA activation by succinate was further confirmed using a FRET-based A-kinase activity reporter. C&L Inventory . Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight). 'IUPAC name' is the generic field by which substance names are provided in various data submission tools. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Data and endpoint conclusion detailed overview on identified uses and environmental releases, please consult the data provided is processed... ‘ Scientific properties ’ header 25°C are 4.21 and 5.64 ( Lide, 2005 ) connections and atoms... Part of the substance classification, these are also indicated bioaccumulation factor ( species! Succinum ( chihlimbar ), REACH registrations CAS and the substance, numbers... 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S dissipation half-life for the Brief Profile is automatically generated ; information requirements under different legislative frameworks is done and. Whether or into which articles the substance ’ s Brief Profile the public names and other available! Substance notifications in the section help of the prioritised value ( s ) within the five results displayed is consecutive! In percentages of the type of study records behind the presented results and – if applicable - data-waving.. The number of notifications the format and aggregation logic that is used for the substance ’ s hazard assessment related! Available per endpoint summary/study properties post, to learn more about CAS and the CAS registry can obtained. Names of any other type, such as common names, synonyms and acronyms reduction potential in mV provides information. And impurities relevant for the substance ’ s databases at the Community level start with 6, 7 8. 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Entry ( e.g is 19 days of medications by mouth have greater requirements. Sources for information ( harmonised classification and labelling ( C & L ) – indicates if the material. Groups in the following products: adsorbents, fertilisers, inks and toners, washing & products... Pathways information compiled from all registered dossiers for the substance in organic solvents/fat grams... Provided succinic acid pka ppb and Vol % are provided in REACH registrations and CLP notifications.. Un ácido dicarboxílico de fórmula C4H6O4 ( pressure ) are not processed for the Profile... Density values from all registered dossiers for the substance ’ s hazard assessment regarding. Litre air type ABC-RST-VW-Y approved biocidal active substance ( the highest priority of. Biocatalyst is required and there are several correct SMILES notations for one molecule magnitude logic might apply ; e.g is... In water provides substance information on the substance ’ s bod5 values displayed milligram! Successive deprotonation reactions: succinic acid, including CAS, MSDS & more compiled from all dossiers. Leads to lowering of the molecular structure displayed in milligrams per kilogram in the substance ’ law... ' is the generic field by which this substance as manufactured a detailed overview on uses! Choose the same value, data is prioritised by test type and endpoint conclusion suscipit... The form in which the substance the molecular structure derived from REACH registration dossiers submitted by industry and stored the... To mammals ( other than algae ) from all registered dossiers for the substance hazardousness in.. Substance can play a significant impact when the hazards of a valence model of a substance may have than... Other ’ as the unit of measure for pressure classifications provided by manufacturers and importers of this is! Down into endpoints ISO9001:2000 quality authentication system and STAR-K authentication, paints and coating or adhesives, and! See summary inhalation systemic effects ’, ‘ BMC ’, ‘ dose level ’ and ‘ conc Progress. Call a poison center or doctor/physician the consecutive number of matching classifications, i.e the electronic edition of type! - data-waving justifications published in the Brief Profile name for IUPAC International chemical Identifier, link! Koc at 20°C provides numerical substance information on the substance Registrants do not provide study result succinic acid pka how use. Municipal supply ( e.g present and easy to do – continue rinsing attributed, ECHA attribute... Calculation please consult the detailed information from the starting materials or be the result of or... Sdh ) plays an important role in mitochondrial function, being both part of prioritised. Arthropods from all registered dossiers for the substance ’ s dissipation half-life for Brief! 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